A research team led by Professor Soon Young Shin of the Department of Biological Sciences has identified that agerarin is a bioactive compound in AHE responsible for CLOCK-mediated AQP3 expression in keratinocytes.and demonstrated that agerarin can be used as a potential adjunct to enhance the treatment of various skin diseases by providing adequate hydration in the epidermis. The study was published in Scientific Reports, an online open access scientific mega journal published by the Nature Publishing Group, in an article titled “Agerarin, identified from Ageratum houstonianum, stimulates circadian CLOCK-mediated aquaporin-3 gene expression in HaCaT keratinocytes”. This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (grant no. 2016R1A2B4008570) and by the Cooperative Research Program for Agriculture Science & Technology Development (project no. PJ011884022016; Rural Development Administration), Republic of Korea. This paper was supported by the KU Research Professor Program of Konkuk University.