- 건국대학교

	KU Prof. Kyun-hwan Kim, discovered antiviral active protein of cytokines against hepatitis B virus
	관리자		550		2018.08.30

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Professor Kyun-hwan Kim’s team (Graduate School of Medicine) of Konkuk University, discovered a new antiviral active protein of cytokines against hepatitis B virus (HBV) which can be a great help for treatment of chronic hepatitis B infection.
On Aug 23th, Konkuk University said that Professor Kyun-Hwan Kim, Dr. Doo Hyun Kim, and Professor Eun-Sook Park discovered a new protein that uses hepatocytes to remove the hepatitis B virus.
Hepatitis B virus is the main cause of chronic hepatitis, liver cirrhosis and liver cancer. If our body got infected by this virus, our body secrete cytokine and remove the virus.
However it is not well known that how cytokine (protein which is secreted from the cell and can affect the cell itself or other cells and includes tumor necrosis factor and interferon.) causes antiviral effect through which protein.
The research team discovered the principle which the protein called interleukin-32 is made by cytokines and it involves in virus removal.
Meaning that unlike existing interleukins which are secreted externally, it eliminates the virus by regulating signal inside of hepatocytes.
Interlleukin-32 is a potent antiviral protein which directly inhibits transcription and replication of viruses.
Through the research, the research team showed that interleukin-32 is an important rationale for treating viral liver disease.
These results are significant in that it has high possibility of being used in the development of therapeutic agents for chronic hepatitis B in the future.
Professor Kyun-Hwan Kim said that “We specifically found out the molecular mechanisms regarding which tumor necrosis factors and interferon-gamma removes the hepatitis B virus as mediation without any damage of hepatocellular” and “It will be a great help in the treatment of chronic hepatitis B in the future.”
The research was carried out with support from the Ministry of Science, Technology, and Information Technology, and the Korea Research Foundation’s Basic Research Project.
The research results are published online in the international journal, Nature communications.

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