- 건국대학교

	Prof. Jin Hoi Kim's research team studied how microRNA makes an effect on infertility
	관리자		510		2018.09.13

<img style="margin-left: auto; display: block; margin-right: auto;" src="ArticleFile.do?id=11742107" width="189" height="270" /> Professor Jin Hoi Kim's research team of Konkuk University's Stem Cell and Regenerative Biology department recently analyzed how microRNA effect on reproductive cell's occurrence, differentiation, fertilization, and implantation, and suggested the possibility of development of infertility treatment. Micro RNA (microRNA, miRNA) is a small RNA which controls gene expression of mammal and consisted of 20-25 nucleotides which ordinary mRNA is consisted of thousands of nucleotide. These micro RNA is known as regulating 33% of entire genes existing in mammals, and one microRNA is known as controlling 400 genes at the same time. Recent research suggests that these microRNAs play a crucial role as a key factor in regulating germinal connective tissue formation and regulating gonad cells.  
Despite the US Food and Drug Administration approved RNA-interference basis treatment for the first time on 10th of this month, which has been controversial for last 2 decades, established foundation for various diseases treatment, academia and the medical community evaluated that it is difficult to commercialize for infertile patients because of difficulty in analyzing the correlation of RNA with human infertility. 
The research team has succeeded categorizing the entire microRNA involved in the development, differentiation, fertilization, embryogenesis, fertilization as well as infertility and fertility of germ cells systematically for the first time by analyzing the entire 2588 microRNA existing in human beings. Based on these microRNA classifications, the research team classify how microRNAs in germ cells are involved in the development of germ cells by interacting with sex hormone-secreting cells of pituitary gland, and suggested the cause of infertility and the direction of medicine development, by linking them to the results of transgenic mouse studies on microRNAs how they relate to infertility.
Professor Kim said that “In this paper, it is significant to provide a breakthrough in how microRNA technology can be applied to a variety of congenital infertility fields and how they can be used for development of infertility drugs."
The paper of Professor Kim’s research team was published online in the Biological Reviews, published by the international journal, ‘Cambridge Philosophical Society’ (the title of the paper: Roles of microRNAs in mammalian reproduction: from the commitment of germ cells to peri-implantation embryos) (Biological Reviews; IF: 11.7) on August 28th.
This work was supported by the Science Research Center (2015R1A5A1009701) from the National Research Foundation of Korea.
 <img style="margin-left: auto; display: block; margin-right: auto;" alt="" src="ArticleFile.do?id=11742102" width="603" height="453" /> 
Figure 1. Cell-specific role of microRNAs on the development and differentiation of germ cells. MicroRNA plays an important role not only for development and differentiation of male and female germ cells, but also in fertilization and fertilization.
 <img style="margin-left: auto; display: block; margin-right: auto;" alt="" src="ArticleFile.do?id=11742103" width="537" height="403" /> 
Figure 2. MicroRNAs are directly or indirectly involved in the development, differentiation and maturation of male cells by regulating hormone-producing cells and their signals. And these abnormalities in signal transduction lead to abnormalities in spermatogenesis, resulting in male sterility.
 <img style="margin-left: auto; display: block; margin-right: auto;" alt="" src="ArticleFile.do?id=11742104" width="582" height="437" /> 
Figure 3. MicroRNAs are directly or indirectly involved in the development, differentiation and maturation of magnetic cells by regulating the signal with hormone-producing cells. These abnormalities in signal transduction cause abnormalities in oocyte development, resulting in female infertility.
 <img style="margin-left: auto; display: block; margin-right: auto;" alt="" src="ArticleFile.do?id=11742105" width="589" height="442" /> 
Figure 4. MicroRNAs are directly or indirectly involved in the fertilization of embryos, by regulating the signal with the endometrial cells that prepare the implant. These abnormalities in signal transduction cause miscarriages and abnormalities of development, resulting in abortion.


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