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KU Professor’s Research Published in Stem Cell Reports
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865
2018.04.10
<div style="text-align: justify;"> <p>A research team lead by Professor Dong-wook Han of the Department of Stem Cell Biology, School of Medicine, succeeded in directly converting mouse fibroblasts into cholangiocyte progenitor cells. <br /><img alt="" src="ArticleFile.do?id=11728529" width="261" height="389" /><br />They found that the expression of Hnf1α and Foxa3 dramatically facilitates the robust generation of iHepSCs and prolonged in vitro culture of Hnf1α- and Foxa3-derived iHepSCs induces a Notch signaling-mediated secondary conversion into cholangiocyte progenitor-like cells that display dramatically enhanced differentiation capacity into mature cholangiocytes. It is expected that the technology will play a pivotal role in developing cell therapy products and new drugs for cholangiocyte-related diseases.<br /><img alt="" src="ArticleFile.do?id=11728530" width="400" height="400" /><img alt="" src="ArticleFile.do?id=11728531" width="571" height="199" /><img alt="" src="ArticleFile.do?id=11728532" width="570" height="181" /><br /><br /></p> <p>This research, titled “Direct Conversion of Mouse Fibroblasts into Cholangiocyte Progenitor Cells”, published in Stem Cell Reports, a monthly peer-reviewed open access journal covering research into stem cells, was supported by National Research Foundation of Korea (NRF) grants funded by the Korean government (MSIP)</p> <p>*This study’s co-authors include Kyung-tae Lim, MD, and Jong-hun Kim and Seon-in Hwang, PhD students at the School of Medicine.</p> </div>
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