- 건국대학교

	KU research team to Clarifies three Stem Cell Energy Metabolism from Early Embryo
	관리자		410		2020.02.05

Professor Jeong-tae Do’s research team(co-first author, master's program student, Choi Jun-hyuk and Ph.D. student Bong-jong Seo), KU Institute of Technology, has made three stem cells derived from blastocysts (early embryonic stem cells, trophic stem cells, Primitive endoderm stem cells) and revealed the differences in mitochondrial morphology, energy metabolism, and gene expression patterns of these three stem cells. <img style="margin-left: auto; display: block; margin-right: auto;" alt="" src="ArticleFile.do?id=11780925" />　　　    Professor. Jung Tae Do                    Master's program student                          Ph. D student                                                                                   Joonhyuk Choi                                  Bong Jong Seo  This research was supported by the SRC Support Program and the Biomedical Technology Development Program. The paper was published in the February issue of Redox Biology. Title of paper: Comparative analysis of the mitochondrial morphology, energy metabolism, and gene expression signatures in three types of blastocyst-derived stem cells
Three types of stem cells, which are established in early embryos (blastocysts) by professor Do, ES cells, TS cells, and XEN cells, have different potentials and features. The team found differences in their mitochondrial morphology and energy metabolism. Embryonic stem cells and trophoblastic stem cells had round immature forms of mitochondria, and primitive endoderm stem cells had a mature mitochondrial form that was relatively longer than the other two stem cells. Because mitochondria play a role in producing the necessary ATP cells, the mitochondrial morphology differs in energy metabolism in other stem cells. There are two ways to produce ATP in cells: glycolysis and oxidative oxidation (electron transfer system). Glycolysis occurs in the cytoplasm, and the electron transport system is the reaction that occurs in the mitochondria. Primitive endoderm stem cells with relatively mature mitochondria produced ATP mainly by oxidative oxidation by mitochondria. KU research team also measured the amount of ATP produced by the three stem cells. The stem cells that produce the most ATP are trophoblast stem cells and the stem cells that produce the least ATP are embryonic stem cells. Although embryonic stem cells and trophoblast stem cells have a similar mitochondrial shape, there was a fourfold difference in ATP production. The Ph. D student, Bong Jong Seo said that "this study suggests that ATP demand and production can be determined by cell type and function rather than mitochondrial morphology. In addition, the energy metabolism of various cells in their early developmental stages suggests that simple interpretation may be difficult."
 <img style="margin-left: auto; display: block; margin-right: auto;" alt="" src="ArticleFile.do?id=11780926" width="604" height="412" /> 
Corresponding author: Professor Jung Tae Do(Department of Stem Cell and Regenerative Biology, Konkuk University, dojt@konkuk.ac.kr) Co-first author: Joonhyuk Choi(a master’s program student of Stem Cell and Regenerative Biology, Konkuk University) and Bon Jong Seo(Ph. D student of Stem Cell and Regenerative Biology, Konkuk University)


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