- 건국대학교

	Prof. Junghyang Sur’s Team Completes Genetic Mapping of Mutations in Dogs
	관리자		469		2020.08.10

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A Korean research team with Professor Jung Hyang Sur at Konkuk University College of Veterinary Medicine, has successfully discovered the patterns of genetic mutation of dog tumors. Although the genetic information of dogs was decoded 15 years ago, it is the very first mapping that comprehensively examines mutations in all types of genes that may possibly result in tumor.
The joint research team comprised of Professor Sang Woo Kim of Yonsei University College of Medicine, Catholic University College of Medicine, Konkuk University College of Veterinary Medicine and Gwangju Institute of Science and Technology succeeded in completing the genetic mapping of mutant tumors in dogs and identified the patterns of genetic mutation by analyzing genes of 191 dogs with mammary tumors. (Thesis title: Cross-species Oncogenic Signatures of Breast Cancer in Canine Mammary Tumors)
The genetic mapping of mutations includes all types and frequencies of genetic mutation which repeatedly occur in a single disease, and can be significantly applied in studying the cause, diagnosis and treatment of the disease.
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Precision Medicine, which provides optimal treatment based on the characteristic genetic variation of individual patients, is being already used as most genetic mutations which may cause cancer have been revealed. However, genetic mutations leading tumor in dogs which are known to suffer from human-like forms and processes have not been clarified yet.
Accordingly, the research team completed the genetic mapping of mutations by examining genetic information in 191 cases of mammal tumors in dogs and its samples in Korea.
As a result of comparing major genes(PIK3CA, PTEN, TP53, BRCA) that show mutations in genetic mapping of dogs with mammary tumors and breast tumors, it is found out that the mutations occur in similar location with similar frequency.
The research team also presented the existence of subtype, which is the same mammary tumor with poor prognosis, depending on the degree of gene manifestation. These subtypes are also found to be closely related to those of humans.
This finding can be a theoretical basis in that it applies the approaches to human cancer to dogs’ treatment by demonstrating that genetic mutation, which is the core between human and dogs, and subtype of tumors are maintained. As the team analyzed naturally developed cancer in dogs living in same environment as humans, the finding can be also used to better understand human cancer.
Professor Sur stated that, “This research is more likely to be applied in diagnosis than treatment.” and stressed the meaning by saying that “We will make the most of the findings to provide easy, fast and accurate diagnosis of blood cancer, etc.
The result of the research was published in the international journal ‘Nature Communications’ on the 17th.
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