- 건국대학교

	Prof. Jungsoo Yoo's Team Identifies Genetic Mechanism of Liver Cancer
	관리자		347		2021.01.25

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Research team of Professor Jungsoo Yoo from Konkuk University’s Graduate School of Medicine first identified that ‘SMARCB1’, known as the suppressor gene, may cause tumors in liver cancer. The research team also presented molecular biological mechanisms and treatment strategies to restrain them. (Thesis title: Nucleoporin 210 Serves a Key Scaffold for SMARCB1 in Liver Cancer)
The research results, which was conducted by National Research Foundation of Korea (Ministry of Science and ICT) to support basic research, was published online on the 17th in top 7.58% oncology journal ‘Cancer Research’ (IF 9.727) compiled by American Association for Cancer Research.
With the development of vaccines and antiviral drugs for Hepatisis B, the rate of liver cancer was expected to decline. However, it still shows high record on mortality rate. In overall cancer mortality among middle-aged patients in their 40s and 50s, in particular, liver cancer is taking first place causing great social and economic losses.
A number of genetic variability and abnormal expressions of chromatin remodeler are being found in many types of cancer thanks to the recent development of technology such as NGS (Nest Generation Sequencing) and active genetic consortiums around the world. Yet, its role and fundamental mechanism are not fully understood.
The research team of Professor Yoo studied SMARCB1, a subunit of chromatin remodeler as well as tumor suppressor, and its role in liver cancer. Surprisingly, the team revealed that SMARCB1 is highly upregulated and related to poor prognosis in liver cancer patients.
The research team discovered that NUP210, the nuclear membrane protein, is a major target for SMARCB1 in liver cancer resulting from comprehensive analysis of SMARCB1 and H3K27Ac based on gene expression and chromatin binding following SMARCB1 loss. The team also found out that SMARCB1 controls changes in cholesterol homeostasis and xenobiotic metabolism by concentrating and expressing genes of H3K27AC when it binds to NUP210 Enhancer, the nuclear membrane protein, and NUP210 can become a new tumor support in liver cancer. The overexpression of SMARCB1 leads structural change of chromatin in NUP210 Enhancer, and results in cancer incidence by inducing abnormal gene expression.
Professor Yoo said, “We have identified a mechanism that SMARCB1, known as a tumor-suppressing gene, may contribute to liver cancer incidence causing structural changesW in chromatic,” adding that, “We believe that the founding can also be used to develop treatments for various cancers including genetic variation or abnormal expressions of chromatin remodeler.”
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